Parasites and Ulcerative Colitis: Debunking the Parasite Cleanse Trend
- Jacki McEwen-Powell

- Mar 25
- 5 min read
Lately, there’s been a surge in talk about parasites being the root cause of ulcerative colitis (UC), with people turning to parasite cleanses, and even Ivermectin as potential solutions. It’s tempting to believe that a simple cleanse could resolve UC, but this trend raises some serious concerns.

While parasites can cause gut issues, blaming UC entirely on parasites oversimplifies a complex condition and self-treating with intense cleanses can do more harm than good.
So, let’s break this down:
Can parasites really cause UC? Is a cleanse ever helpful? And most importantly, how can you tell if you actually have a parasite?
Can Parasites Cause Ulcerative Colitis?
The idea that parasites are the root cause of UC is not supported by current science. UC is an autoimmune condition in which the immune system mistakenly attacks the lining of the colon, triggering inflammation and ulceration. While gut infections can sometimes mimic UC symptoms, true UC is not caused by parasites.
That said, parasites can contribute to digestive distress, and some infections may worsen UC symptoms or trigger flares. However, these cases are the exception rather than the rule.
Research suggests that parasites like Entamoeba histolytica, Blastocystis hominis, and Giardia can cause symptoms that overlap with UC, such as diarrhea, abdominal pain, and fatigue. But these are distinct infections that require specific treatment — not an aggressive cleanse unless medically indicated.
Key Fact: UC has strong links to immune dysfunction, gut microbiome imbalances, and inflammation. While parasites can trigger temporary gut issues, they are not a proven root cause of UC itself.
For more on UC’s root causes, check out Crohn's & Colitis Foundation.
Are Parasite Cleanses Safe?
Parasite cleanses often involve strong herbs, essential oils, or supplements designed to kill off parasites. While these remedies may be effective if you have a confirmed parasite, they can be harsh on the body, especially if you’re already managing UC.
What About Ivermectin?
Ivermectin, an antiparasitic medication, has gained attention recently as part of the parasite cleanse trend. While ivermectin is an FDA-approved drug for treating certain parasitic infections (like strongyloidiasis and onchocerciasis), it is not approved for the treatment of UC.
Self-medicating with ivermectin can be risky. It can cause side effects like nausea, dizziness, and neurological issues and there's no scientific evidence that it improves UC symptoms unless you have a confirmed parasitic infection. Using Ivermectin without proper diagnosis or guidance may do more harm than good.
For official guidance on ivermectin use, visit the FDA website.
Potential Risks of Parasite Cleanses in UC
Irritating the Gut Lining: Many cleanse ingredients, such as wormwood, black walnut, or clove, are highly potent and can irritate an already inflamed gut. This may worsen UC symptoms and trigger flares.
Microbiome Disruption: Parasite cleanses can wipe out beneficial bacteria, potentially worsening gut dysbiosis — a key driver in UC.
Detox Symptoms: Aggressive cleanses can cause headaches, fatigue, nausea, and diarrhea, which may be confused with UC flares.
Dehydration and Nutrient Loss: Some cleanses have a laxative effect, which can lead to dehydration and poor nutrient absorption — both major risks for UC patients.
Risk of Medication Interactions: Some herbs commonly used in cleanses can interfere with medications, including UC treatments like mesalamine or immunosuppressants.
How to Know if You Have a Parasite
Before jumping into a parasite cleanse, it’s crucial to know whether parasites are actually the issue. The good news? There are reliable tests available.
Testing for Parasites
Stool Tests: Comprehensive stool tests, like the GI-MAP Test or PCR Stool Testing, can identify common parasites along with bacteria, fungi, and other pathogens.
Blood Tests: Some parasites, particularly those that leave the gut and enter the bloodstream, can be detected through antibody blood tests.
Ova and Parasite (O&P) Tests: This traditional test looks for parasite eggs in stool samples but may miss low-level infections.
If you’re experiencing unexplained diarrhea, abdominal pain, or persistent gut issues, testing before treating is the safest and most effective approach.
For reliable testing advice, visit The Cleveland Clinic.
What If You DO Have a Parasite?
If testing confirms a parasite infection, your doctor may recommend one or more of the following approaches:
Prescription Medications: These are often the safest and most effective way to eliminate parasites without harming your gut.
Natural Remedies: Some herbs like garlic, oregano oil, or berberine can help, but they should be used carefully and under guidance.
Gut Support Protocols: Restoring microbiome balance with probiotics, fermented foods, and prebiotic fibers is key to strengthening your gut after treatment.
What Happens if You Do a Parasite Cleanse Without Needing One?
Here’s where things get risky. If you don’t have a parasite but still attempt a cleanse, you may end up:
Weakening Your Gut Lining by overloading your digestive system with harsh ingredients.
Triggering a UC Flare by disrupting your already sensitive gut microbiome.
Exhausting Your Body’s Reserves with detox symptoms that resemble a flare, making it harder to recover.
In short, a parasite cleanse should only be done if there’s clear evidence you need one — and ideally under professional guidance.
FAQs About Parasites, UC, and Cleanses
1. Can parasites trigger UC flares? Parasites can cause temporary gut inflammation, which may trigger a flare in people already living with UC. However, parasites themselves are unlikely to be the root cause of UC.
2. What are common symptoms of a parasite infection? Symptoms can include diarrhea, abdominal cramping, unexplained weight loss, bloating, fatigue, and nausea. These symptoms often overlap with UC, which is why proper testing is important.
3. Are there gentle ways to support gut health without a cleanse? Absolutely. Instead of a harsh cleanse, focus on strengthening your gut with anti-inflammatory foods, probiotics, and gut-healing supplements. Adding garlic, ginger, or oregano to your diet can offer antimicrobial benefits without risking a flare.
4. How long does it take to recover from a parasite infection? Recovery time varies. With appropriate treatment, symptoms often improve within a few weeks. Supporting your gut with probiotics and soothing foods can speed up recovery.
5. Should I avoid all parasite cleanses if I have UC? Not necessarily. If testing confirms a parasite infection, a carefully guided cleanse or prescription treatment may help. The key is to avoid self-treating based on suspicion alone.
The Bottom Line
While parasites can cause gut issues, they are not the cause of UC. The recent trend of parasite cleanses is concerning because aggressive treatments can irritate the gut, disrupt your microbiome, and trigger UC flares if they aren’t truly needed.
If you’re dealing with unexplained symptoms or concerned about parasites, testing is the safest way forward. Your gut is already working hard to manage inflammation, so avoiding unnecessary treatments can help you stay on track.
If you’ve been tempted by a parasite cleanse or heard confusing claims, I hope this clears things up. Have questions? Drop them in the comments, and I’ll do my best to help.
For additional guidance, visit trusted resources like the Mayo Clinic or The Cleveland Clinic.
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